Chemistry – Syllabus

All Courses 4 Credits (Theory Courses roughly 40 hours), Labs- 13 sessions, each 3 hours

Semester II (3 courses)

• Topics in Chemistry: Theory
• Energetics of Change:  Theory Course

System and surroundings, state function and path function, Four laws of thermodynamics, internal energy, enthalpy, entropy, free energy and chemical potential, criteria for spontaneous change, Temperature and pressure dependence of free energy and chemical potential, chemical equilibrium and phase equilibrium, Phase diagram.

• Introductory Laboratory  Course: Lab course

Semester III (3 Courses)

• Basic Inorganic Chemistry:  Theory Course

• Concepts in Organic Chemistry: Theory Course

Organic Chemistry in day to day life: General applications of carbon compounds in day to day life.  

• • Structure and bonding: Ionic, Covalent, Coordinate and Hydrogen bonds, The octet rule,  Formal charge, Sigma (σ-) and pi (π-) bonds,  Hybridisation, , Inductive effects, Hyperconjugation, Mesomeric effects, Steric effect,  Acidity and basicity, Acids, Bases 
  • Nomenclature:  Functional groups, IUPAC Nomenclature of aliphatic organic compounds: Alkanes, Alkenes, Alkynes, Alcohols, Amines, Carboxylic acids, Ethers, Halides, and nitriles.
  • Aromaticity: Hückel’s rule and characteristics of aromatic compounds benzenoid and non-benzenoid compounds, Alternant and nonalternant hydrocarbons, Annulenes, Anti-aromaticity, Homo-aromaticity and Nomenclature of aromatic compounds.
  • Stereochemistry: Representation of stereostructures: Fischer, Newmann, and Sawhorse Projection formulae and their interconversions.
  • Conformational analysis: Butane and cyclohexane (mono and disubstituted) and their relative stability and energy diagrams.
  • Configurational analysis: Geometrical isomerism: cis–trans, syn-anti, and E/Z notations with C.I.P rules.
  • Optical isomerism: Chirality, Enantiomers, The Cahn–Ingold–Prelog (R and S) nomenclature, The D and L nomenclature, Diastereoisomers (or diastereomers), Diastereoisomers,  Mesomer Racemic mixture,  resolution of racemic mixture and ee%
• Atoms, quanta, and light:  Theory Course

Dual behavior of light and particle, Postulates of quantum mechanics, particle in a box, rigid rotor, harmonic oscillator, hydrogen atom, rotational spectra, and vibrational spectra.

Semester IV ( 4 Courses)

• Inorganic Chemistry: Theory Course

Structure and Bonding of Inorganic Molecules including Coordination, and Organometallic  compounds and molecules of biological importance

• Rate, order and mechanism: Theory Course 

Rate of a reaction, order and molecularity of a reaction, determination of order and rate constant of the reaction, Arrhenius equation, collision theory, Transition state theory, parallel, consecutive and reversible reaction, determination of reaction mechanism from rate law.

• Elective- 1: Theory Course
• General Chemistry Laboratory I :  Lab course 

Semester V ( 3 Courses)

• Mechanistic Organic Chemistry I : Theory Course
  • Language of arrows: straight arrow, curved arrow, half headed arrows and double headed arrows
  • Bond cleavage: Homolytic & Heterolytic bond
  • Reaction intermediates formation, stability and reactivity: Carbocation, Carboanion, Free radicals, Carbene, Nitrene, Benzyne
  • Type of Reagents: Electrophile & Nucleophiles
  • General types of reaction
  • Addition reactions:  Electrophilic & Nucleophilic addition, Markonikoff & Anti Markonikoffs Rule
  • Elimination reactions: E1, E2 and E1CB, Factors affection elimination reaction, Energy profile diagram
  • Substitution reactions: SN1 and SN2, SNi, Factors affection substitution reaction Energy profile diagram, Anchimeric Assistance, Substitution reaction in aromatic compounds
  • Condensation reactions: Aldol condensation, Dieckmann condensation, Claisen condensation, Enamine and Imine formation
  • Pericyclic reactions:  Woodward Hoffman Rule and Molecular Orbital Theory Diels Alder reaction
  • Rearrangement reactions: Carbocation, Carboanion, Free radicals, Carbene, Nitrene intermediates
• Modern Methods of Analysis and Characterization: Theory Course

Introduction to Spectroscopic, Microscopic and Diffraction methods, Electroanalytical and thermal Methods,

• General Chemistry Laboratory II : Lab Course

Semester VI ( 3 Courses)

• Mechanistic Organic Chemistry II: Theory Course

  • Reagents in Organic Synthesis: 

  • Organometallic Reagents: Organomagensium, Organolithium, Organocopper, Organosilicon, Organoboron, Organozinc. 

  • Oxidising Reagents: PCC, PDC, DDQ, OsO4, KMnO4, MnO2, Jones reagent, Collins reagent, Oxalyl chloride, Al(iPrO)3, TEMPO, HNO3, Dess-Martin Periodinane 

  • Reducing Reagents: LiAlH4, NaBH4, DIBAL-H, Red-Al, Lindlar’s catalyst, Rosenmund catalyst, H2, Raney nickel, Adams Catalyst, Na-liqNH3, Al(iPrO)3, Wilkinson’s catalyst, Sn/HCl, N2H4/OH-

  • Name Reactions: Wittig reaction, Simmons-Smith Reaction, Ene Reaction, Cope Elimination reaction, Click reaction, Sharpless epoxidation

  • Designing Organic Synthesis:  Retrosynthesis and disconnection approach

  • Synthesis of natural product: (±) Estrone, Mifepristone (Ru-486) And Its Analogues

References: 

1. Principle of organic synthesis, R. O. C. Norman and J. M. Coxon

2. Advanced Organic Chemistry: Part A: Structure and Mechanisms  by Francis A. Carey  and Richard J. Sundberg  

3. Organic Chemistry by Jonathan Clayden, Nick Greeves and Stuart Warren

4. Designing Organic Syntheses: A Programmed Introduction to the Synthon Approach by Stuart Warren

• Elective 2: Theory Course
• Elective 3: Research  project
• Suggested Electives: (3 electives to be chosen, prerequisites to be detailed)

1. 1. Applied Organometallic & Coordination Chemistry
   2. Environmental Analysis
   3. Chemical Biology
   4. Chemistry of Materials
   5. Renewable Energy: Hydrogen and Solar Energy
   6. Materials at nanoscale
   7. Computational Chemistry and Molecular Simulation
   8. Environmental Chemistry
   9. Energy Materials: Batteries, Super capacitors etc

• Advance  General  Chemistry  Laboratory