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X-ORIGINAL-URL:https://www.ashoka.edu.in
X-WR-CALDESC:Events for Ashoka University
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TZID:Asia/Kolkata
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TZOFFSETFROM:+0530
TZOFFSETTO:+0530
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DTSTART:20210101T000000
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DTSTART;TZID=Asia/Kolkata:20221118T100000
DTEND;TZID=Asia/Kolkata:20221118T113000
DTSTAMP:20221028T035517Z
CREATED:20221028T035517Z
LAST-MODIFIED:20221028T035517Z
UID:36819-1668765600-1668771000@www.ashoka.edu.in
SUMMARY:Cyclotron Resonance in Astrophysics
DESCRIPTION:Abstract: Cyclotron resonance arises when free electrons encounter an ambient magnetic field. In the cosmic setting such a situation is often encountered\, and cyclotron resonance shapes the spectra of a large variety of objects\, starting from the Earth's aurora to neutron stars and active galaxies. The resonance also leads to Maser activity in many cases. In this colloquium the phenomenon of cyclotron resonance will be introduced and different physical situations where this manifests will be described. Use of cyclotron resonance to estimate the magnetic field strengths of different objects will be discussed. \nSpeakerBio: Dipankar Bhattacharya is the Sunanda and Santimay Basu Professor in Astrophysics at Ashoka University and is currently the Head of the Physics Department. Prior to joining Ashoka he was the Dean\, Core Academic Programmes at Inter-University Centre for Astronomy and Astrophysics in Pune. He obtained his Masters' degree in Physics from Jadavpur University\, Kolkata and his PhD from the Indian Institute of Science\, Bengaluru. His research focus is on High Energy Astrophysics\, including Compact Objects and Explosive events.
URL:https://www.ashoka.edu.in/event/cyclotron-resonance-in-astrophysics/
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DTSTART;TZID=Asia/Kolkata:20221118T140000
DTEND;TZID=Asia/Kolkata:20221118T150000
DTSTAMP:20221115T012639Z
CREATED:20221115T012639Z
LAST-MODIFIED:20221115T012639Z
UID:37600-1668780000-1668783600@www.ashoka.edu.in
SUMMARY:Biomolecular Condensates formed via Liquid-Liquid Phase Separation of Intrinsically Disordered Prote
DESCRIPTION:Abstract: \nLiquid-liquid phase separation (LLPS) of intrinsically disordered proteins/regions (IDPs/IDRs) into intracellular biomolecular condensates is involved in critical cellular functions. However\, aberrant phase transitions are associated with debilitating neurodegenerative diseases. We show that the prion protein (PrP) can undergo LLPS via weak\, multivalent\, transient intermolecular interactions between the N-terminal IDR that resembles a yeast prion-like domain comprising five glycine-rich octapeptide repeats and a hydrophobic segment. An intriguing disease-associated amber stop codon mutation (Y145Stop) yields a C-terminally truncated intrinsically disordered fragment that is associated with Gerstmann-Sträussler-Scheinker syndrome and familial cerebral amyloid angiopathy. We demonstrate that Y145Stop spontaneously phase-separates into highly dynamic liquid droplets under physiological conditions. Our bioinformatic\, spectroscopic\, microscopic\, and mutational studies coupled with single-droplet vibrational Raman spectroscopy revealed highly dynamic internal organization within condensates and illuminated the critical molecular drivers of LLPS of Y145Stop. We also show that Y145Stop exhibits a reentrant phase behavior in the presence of RNA. Upon aging\, these highly dynamic liquid droplets undergo a liquid-to-solid phase transition into highly ordered\, beta-rich\, amyloid aggregates that exhibit a characteristic autocatalytic self-templating behavior. Therefore\, LLPS-mediated amyloid formation can potentially represent a noncanonical phase transition pathway to self-replicating prions. The propensity for this aberrant phase transition is much lower for the full-length PrP indicating an evolutionarily conserved role of the folded C-terminal domain. I will also discuss our recent results on spatiotemporal modulation in complex coacervation of PrP and alpha-synuclein into multicomponent\, multiphasic\, hollow condensates. These multicomponent condensates can act as reaction crucibles to catalyze the amyloid conversion of these functional assemblies into pathological aggregates associated with overlapping neuropathological features. I will also discuss our latest work on the characterization of biomolecular condensates using ultrasensitive vibrational Raman spectroscopy. \n  \nAbout Speaker: \nDr. Samrat Mukhopadhyay graduated with a MS in 2000 then obtained his PhD in Organic Chemistry in 2004 from the IISc Bangalore. He obtained post doctoral from The Scripps Research Institute\, La Jolla\, California\, USA (Molecular Biophysics). He is currently Professor and Head\, Department of Biological science\, IISER Mohali. He is the recipient of numerous Honors and professional recognition\, including recently being Editorial board member\, Biophysical Journal (Cell Press). \n  \n 
URL:https://www.ashoka.edu.in/event/biomolecular-condensates-formed-via-liquidliquid-phase-separation-of-intrinsically-disordered-prote/
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