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PRODID:-//Ashoka University - ECPv6.18.1//NONSGML v1.0//EN
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METHOD:PUBLISH
X-WR-CALNAME:Ashoka University
X-ORIGINAL-URL:https://www.ashoka.edu.in
X-WR-CALDESC:Events for Ashoka University
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X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Asia/Kolkata
BEGIN:STANDARD
TZOFFSETFROM:+0530
TZOFFSETTO:+0530
TZNAME:IST
DTSTART:20220101T000000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Asia/Kolkata:20230906T133000
DTEND;TZID=Asia/Kolkata:20231129T150000
DTSTAMP:20230823T233215Z
CREATED:20230823T232327Z
LAST-MODIFIED:20230823T233215Z
UID:47006-1694007000-1701270000@www.ashoka.edu.in
SUMMARY:Monsoon 23 History events poster
DESCRIPTION:
URL:https://www.ashoka.edu.in/event/monsoon-23-history-events-poster/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Kolkata:20230907T133000
DTEND;TZID=Asia/Kolkata:20231109T150000
DTSTAMP:20230829T051027Z
CREATED:20230829T051027Z
LAST-MODIFIED:20230829T051027Z
UID:47270-1694093400-1699542000@www.ashoka.edu.in
SUMMARY:Monsoon 23 IR Colloquium
DESCRIPTION:
URL:https://www.ashoka.edu.in/event/monsoon-23-ir-colloquium/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Kolkata:20230907T133000
DTEND;TZID=Asia/Kolkata:20231109T150000
DTSTAMP:20230829T051106Z
CREATED:20230829T051106Z
LAST-MODIFIED:20230829T051106Z
UID:47272-1694093400-1699542000@www.ashoka.edu.in
SUMMARY:Monsoon 23 IR Colloquium
DESCRIPTION:
URL:https://www.ashoka.edu.in/event/monsoon-23-ir-colloquium/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Kolkata:20230907T133000
DTEND;TZID=Asia/Kolkata:20231109T150000
DTSTAMP:20230901T001623Z
CREATED:20230901T001623Z
LAST-MODIFIED:20230901T001623Z
UID:47375-1694093400-1699542000@www.ashoka.edu.in
SUMMARY:Monsoon 23 IR Event Poster
DESCRIPTION:
URL:https://www.ashoka.edu.in/event/monsoon-23-ir-event-poster/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Kolkata:20231003T100000
DTEND;TZID=Asia/Kolkata:20231031T173000
DTSTAMP:20240222T010916Z
CREATED:20240222T010916Z
LAST-MODIFIED:20240222T010916Z
UID:55891-1696327200-1698773400@www.ashoka.edu.in
SUMMARY:Dyslexia Awareness Month
DESCRIPTION:Dyslexia Awareness Month \n  \nOctober is celebrated as “Dyslexia Awareness Month''. To mark this month\, every year\, the Office of Learning Support (OLS) organized events to raise awareness and spark conversations about dyslexia\, learning\, and neurodiversity within the Ashoka campus. This year\, OLS joined forces with various student clubs and societies to amplify their endeavors\, engaging students\, staff\, and faculty through creative and enjoyable activities. Throughout the month\, OLS carefully planned a series of events designed to involve the entire Ashoka community in various ways\, with the goal of sharing essential facts about dyslexia and nurturing a culture of acceptance for neurodiversity. \n  \n 
URL:https://www.ashoka.edu.in/event/dyslexia-awareness-month/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Kolkata:20231012T150000
DTEND;TZID=Asia/Kolkata:20231012T160000
DTSTAMP:20231006T025254Z
CREATED:20231006T025254Z
LAST-MODIFIED:20231006T025254Z
UID:50010-1697122800-1697126400@www.ashoka.edu.in
SUMMARY:Signatures of GPCR-lipid Interactions: Specificity\, Synergy and Energetics.
DESCRIPTION:Abstract: \nThe G protein-coupled receptors (GPCRs) are membrane receptors that play a central role in cell signaling and pharmacology. The interaction of lipids with GPCRs has been shown to modulate and dictate several aspects of GPCR organization and function. In this talk\, we will discuss the diversity of lipid interaction sites that have been identified from molecular dynamics studies and compare to structural data. Using coarse-grain simulations\, we identified several GPCR-lipid\, in particular GPCR-cholesterol signatures and highlight the common and specific features. Further\, using a set of similarity coefficients\, we classify lipids that bind at the receptor together as synergistic co-binding\, and those that bind individually as competitive.  Not surprisingly\, the ganglioside GM1 and cholesterol show a synergistic co-binding. In contrast\, certain lipid pairs such as cholesterol and sphingomyelin appear to be in competition at several sites\, despite their co-existence in lipid nanodomains. To quantify these interactions\, we estimate the energetics and dynamics of lipid association. We show that lipids bind to the receptor with varying energetics of 1-4 kT\, and timescales of 1-10 µs. Multi-exponential fitting of the contact probability suggests a three-step model\, that we correlate with the annular\, intermediate and non-annular sites. High barrier heights are estimated between the states that reduce the association/dissociation kinetics. The results highlight that GPCR-lipid interactions are driven by both thermodynamic interactions and the dynamical features of lipid binding. \nAbout the Speaker: \nDr. Durba Sengupta is currently a scientist and Associate Professor (AcSIR) at the National Chemical Laboratory\, Pune\, India. She has been awarded a doctoral degree from the University of Heidelberg\, Germany and subsequently joined the University of Groningen\, Netherlands as a postdoctoral researcher. The main interest of her research group is computational biology\, in particular multi-scale simulations. They have been able to identify the molecular mechanisms underlying membrane protein dynamics and protein-lipid interactions. She has published widely in internationally reputed journals\, and has been invited to international conferences in biophysics and computational biology. Dr. Sengupta is an editor of J. Membr. Biol. (Springer Nature Press) and an editorial board member of Proc. India Nat. Sci. Ac.. and has guest edited special issues for several journals. \n 
URL:https://www.ashoka.edu.in/event/signatures-of-gpcrlipid-interactions-specificity-synergy-and-energetics/
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