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X-WR-CALDESC:Events for Ashoka University
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TZID:Asia/Kolkata
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TZOFFSETFROM:+0530
TZOFFSETTO:+0530
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DTSTART:20220101T000000
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BEGIN:VEVENT
DTSTART;TZID=Asia/Kolkata:20230906T133000
DTEND;TZID=Asia/Kolkata:20231129T150000
DTSTAMP:20230823T233215Z
CREATED:20230823T232327Z
LAST-MODIFIED:20230823T233215Z
UID:47006-1694007000-1701270000@www.ashoka.edu.in
SUMMARY:Monsoon 23 History events poster
DESCRIPTION:
URL:https://www.ashoka.edu.in/event/monsoon-23-history-events-poster/
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DTSTART;TZID=Asia/Kolkata:20231117T150000
DTEND;TZID=Asia/Kolkata:20231117T160000
DTSTAMP:20231108T051942Z
CREATED:20231108T051942Z
LAST-MODIFIED:20231108T051942Z
UID:51791-1700233200-1700236800@www.ashoka.edu.in
SUMMARY:Reductive stress by thiol antioxidants activates the hypoxia response pathway.
DESCRIPTION:Abstract:  \nReductive stress\, caused by an excess of antioxidants\, is linked with several pathological conditions\, including cancer and neurodegenerative diseases. However\, the effects of reductive stress on cellular physiology remain poorly characterized. Using the nematode model Caenorhabditis elegans\, we show that thiol antioxidants such as dithiothreitol (DTT) and β-mercaptoethanol modulate the methionine–homocysteine cycle by upregulating an S-adenosylmethionine-dependent methyltransferase\, rips-1. We carried out genetic screens to understand how thiol antioxidants resulted in the upregulation of rips-1. We discover that rips-1 is highly upregulated in mutants that have constitutive activation of the hypoxia response pathway. On the other hand\, thiol antioxidants-mediated upregulation of rips-1 is fully blocked in mutants defective in hypoxia response. We demonstrate that thiol stress activates the hypoxia response pathway. The activation of the hypoxia response pathway by thiol stress is conserved in human cells. The hypoxia response pathway enhances thiol toxicity via rips-1 expression and confers protection against thiol toxicity via rips-1-independent mechanisms. Finally\, we show that DTT might activate the hypoxia response pathway by producing hydrogen sulfide. Our studies reveal an intriguing interaction between thiol-mediated reductive stress and the hypoxia response pathway. \nAbout the Speaker:  \nDr. Jogender Singh did his Ph.D. at the National Centre for Biological Sciences (NCBS)\, TIFR\, Bengaluru\, in 2015\, and his postdoctoral research at Duke University\, Durham\, NC\, USA\, and the Oregon Health and Science University (OHSU)\, Portland\, OR\, USA. Subsequently\, in January 2020\, he joined the Department of Biological Sciences at IISER Bhopal as an assistant professor. He moved to the Department of Biological Sciences at IISER Mohali at the end of December 2020\, where he currently serves as an assistant professor. His laboratory uses the model nematode C. elegans to understand cellular stress responses and their role in maintaining organismal homeostasis. He has been awarded the Ramalingaswami Re-entry Fellowship and the Har-Gobind Khorana Innovative Young Biotechnologist Fellowship from the Department of Biotechnology (DBT)\, India. He is an associate of the Indian Academy of Sciences\, Bengaluru.
URL:https://www.ashoka.edu.in/event/reductive-stress-by-thiol-antioxidants-activates-the-hypoxia-response-pathway/
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DTSTART;TZID=Asia/Kolkata:20231117T183000
DTEND;TZID=Asia/Kolkata:20231117T200000
DTSTAMP:20231115T022304Z
CREATED:20231115T022304Z
LAST-MODIFIED:20231115T022304Z
UID:52082-1700245800-1700251200@www.ashoka.edu.in
SUMMARY:EVS Colloquium | Threatening Dystopias: Development\, Adaptation\, and Climate Justice| Kasia Paprocki
DESCRIPTION:Please join us for a talk on "Threatening Dystopias: Development\, Adaptation\, and Climate Justice" by Professor Kasia Paprocki\, London School of Economics and Political Science to be held on Friday\, 17 November 2023\, 6:30 PM. (IST) \nZoom meeting Link: https://zoom.us/j/99297787153?pwd=ZWVhOFY1Vkx2WTF3RFdFRjZja3hpdz0 \nAbstract:  In the global imaginary of climate change\, Bangladesh holds a prominent position. Frequently described as the ‘world’s most vulnerable country to climate change’\, the spectre of Bangladesh underwater\, wiped off the map by rising seas\, has given birth to a crisis narrative that obscures how interventions in the environment and social life of the country have already transformed the landscape many times over. Today\, development in Bangladesh is increasingly defined by and through an adaptation regime\, which governs the landscape of possible intervention in anticipation of climate change. It is built on a vision of development in which urbanisation and export-led growth are both desirable and inevitable. For the rural poor\, this entails dispossession from agrarian livelihoods and outmigration. As this shift contributes to the expansion of production of export commodities such as garments and frozen shrimp\, the threat of climate change and its associated migrations is reframed as an opportunity for development and growth. This presentation will draw on over two years of multi-sited ethnographic fieldwork to explore how this adaptation regime is produced\, experienced\, and contested by a variety of actors from rural Bangladesh\, to Dhaka\, the Bangladeshi capital\, to global institutions of development and knowledge production. \nBio: Kasia Paprocki is an Associate Professor in the Department of Geography and Environment at the London School of Economics and Political Science. Her work draws on and contributes to the study of the political economy of development and agrarian change with a focus in South Asia\, with a particular focus in Bangladesh\, where she has worked and conducted research since 2006. She is the author of Threatening Dystopias: The Global Politics of Climate Change Adaptation in Bangladesh (Cornell University Press\, 2001). Links to her other popular and academic publications are available at kasiapaprocki.com. \n  \n 
URL:https://www.ashoka.edu.in/event/evs-colloquium-threatening-dystopias-development-adaptation-and-climate-justice-kasia-paprocki/
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