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X-WR-CALNAME:Ashoka University
X-ORIGINAL-URL:https://www.ashoka.edu.in
X-WR-CALDESC:Events for Ashoka University
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BEGIN:VTIMEZONE
TZID:Asia/Kolkata
BEGIN:STANDARD
TZOFFSETFROM:+0530
TZOFFSETTO:+0530
TZNAME:IST
DTSTART:20230101T000000
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BEGIN:VEVENT
DTSTART;TZID=Asia/Kolkata:20240208T133000
DTEND;TZID=Asia/Kolkata:20240213T143000
DTSTAMP:20240203T220941Z
CREATED:20240203T220941Z
LAST-MODIFIED:20240203T220941Z
UID:55216-1707399000-1707834600@www.ashoka.edu.in
SUMMARY:IR Seminar
DESCRIPTION:This session will explore new trends in the research and historiographical debates about India- India-Pakistan relations by comparing the perspectives of three authors of recent books on the subject. The panel will discuss the changes that have taken place in this field in recent years; why new interdisciplinary and revisionist perspectives are necessary for its development; the reasons for the widespread public interest across the subcontinent about the state of bilateral relations; and predictions about its future. The session shall be informal and interactive\, prioritising student inputs\, and is an opportunity to engage in a wide-ranging conversation about the history and politics of the South Asian region.
URL:https://www.ashoka.edu.in/event/ir-seminar/
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BEGIN:VEVENT
DTSTART;TZID=Asia/Kolkata:20240212T150000
DTEND;TZID=Asia/Kolkata:20240212T160000
DTSTAMP:20240207T232013Z
CREATED:20240207T232013Z
LAST-MODIFIED:20240207T232013Z
UID:55403-1707750000-1707753600@www.ashoka.edu.in
SUMMARY:The Power of Ignorance: Systematic analysis of the unknome.
DESCRIPTION:About the Speaker: \nMatthew Freeman is the Head of the Dunn School of Pathology at the University of Oxford. His first degree was from Oxford\, his PhD from Imperial College\, London\, and he did a postdoctoral fellowship in Berkeley. He returned to the UK to establish his own group at the MRC Laboratory of Molecular Biology in Cambridge\, where he became Head of the Division of Cell Biology\, before moving to Oxford to lead the Dunn School in 2013. \nHis group originally worked on developmental genetics in Drosophila\, but their long-term focus on cell signalling mechanisms steered them towards the cell biology\, genetics and biochemistry of membrane proteins\, with a specific focus on the rhomboid-like superfamily of proteases and pseudoproteases\, which they discovered. Although primarily driven by fundamental discovery science\, their work has the goal of revealing principles relevant to human disease. Recently\, this has included insights into inflammation\, immunity and cancer. \nMatthew Freeman is a past Chair of the British Society of Developmental Biology\, and the Company of Biologists. He currently Chairs EMBO Council. He has a long-standing interest in science policy and served for many years on the executive committee of CaSE (formerly Save British Science). Among other prizes\, he has been awarded the EMBO Gold Medal (2001)\, the Hooke Medal of the British Society for Cell Biology (2003)\, and the Novartis Prize and Medal (2015). He is a Fellow of the Royal Society and the Academy of Medical Sciences. \nhttps://www.scientificamerican.com/article/mapping-the-unknome-may-reveal-critical-genes-scientists-have-ignored/ \n 
URL:https://www.ashoka.edu.in/event/the-power-of-ignorance-systematic-analysis-of-the-unknome/
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BEGIN:VEVENT
DTSTART;TZID=Asia/Kolkata:20240212T183000
DTEND;TZID=Asia/Kolkata:20240212T193000
DTSTAMP:20240205T234225Z
CREATED:20240205T234225Z
LAST-MODIFIED:20240205T234225Z
UID:55286-1707762600-1707766200@www.ashoka.edu.in
SUMMARY:Mitochondrial Structure-Function Relationship in KRAS-induced Senescence During Neoplastic Transform
DESCRIPTION:Abstract: \nMitochondria\, traditionally known for their energy role\, now play a vital part in various cellular functions and redox balance. Cellular senescence\, characterized by stable cell cycle arrest\, has emerged as a multifaceted process with implications in both tumour suppression and progression. Oncogene activation is widely recognized for promoting cell proliferation\, an event crucial for tumorigenesis across various cancer types. Moreover\, it concurrently poses genetic stress that can lead to irreversible growth arrest leading to oncogene-induced senescence (OIS). Mitochondrial structure-function changes are linked to specific oncogenes like KRAS\, influencing tumorigenic or senescent outcomes. We propose that mitochondria are part of the pivotal switch that governs the decision between a cell to undergo neoplastic transformation or to maintain senescence during oncogene activation. Preliminary data reveals mitochondrial length heterogeneity in neoplastic transformed cells expressing higher p16 (senescent marker)\, regulated by Drp-1 (mitochondrial fission protein).  We then aimed to understand how this structure heterogeneity is linked to mitochondrial function changes (oxidation). This led to the development of Mito-Sim2\, a novel approach to visualize oxidative status influencing the structure of individual mitochondria. Initial analysis revealed a certain oxidation level is maintained by smaller fused mitochondrial networks with distinct homeostatic zones. Since OIS utilizes free radicals for senescence induction by exploiting mitochondrial metabolic reprogramming\, we plan to use Mito-Sim2 to understand how mitochondrial oxidation status impacts its structure during oncogene activation. Transfecting non-transformed cells with KRAS mutants yields variable senescence expression\, while OIS effects in neoplastic cells need to be explored. Future plans include clinical studies for comprehensive insights. This project will hopefully help us understand the intricate relationship of mitochondria in oncogene-triggered cellular senescence (OIS) and neoplastic transformation\, promising insights for cancer intervention. \nAbout the Speaker:\nMayank's broad interest lies in disease-oriented research\, particularly in cancer and ageing. After clearing various national eligibility tests he joined the Mitochondrial Structure Function Lab\, where he is trying to unravel the mystery of the underlying mitochondrial biology in the process of senescence and cancer. He obtained his bachelor’s degree from Sri Venkateswara College\, Delhi University in Biochemistry and a master's in Biotechnology from the University of Hyderabad. His master's dissertation work was focused on Expression and Characterization studies of proteins which was supported by a scholarship from DBT\, Govt. of India. Apart from science\, he loves outdoor sports\, road trips\, travelling\, spending time with friends and occasional cooking (Of course\, he is a big-time foodie!).
URL:https://www.ashoka.edu.in/event/mitochondrial-structurefunction-relationship-in-krasinduced-senescence-during-neoplastic-transform/
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