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Biology Colloquium | Chi Keung Lam

November 2 @ 6:00 pm - 7:00 pm

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Event Details

Speaker: Chi Keung Lam
Assistant professor, Department of Biological Sciences, University of Delaware
Title:     Application of iPSC-Cardiomyocytes in Precision Medicine and Target Identification
Meeting ID: 997 9129 3272
 Passcode: qNZfuKSD

Abstract:  Heart disease is one of the leading causes of death in the world and roughly half of those patients survive 5-year after heart failure diagnosis. The shortcoming can be attributed to the heterogeneous nature of heart disease and lack of understanding of the mechanisms that drive disease development. In this presentation, I will introduce the use of cardiomyocytes derived from human induced pluripotent stem cells (iPSC-CMs) in identifying patient-specific response to cardiovascular disease medication and mutation-specific therapeutic target. We were able to identify that iPSC-CMs from different donors exhibit very different response to calcium channel blocker, which may be used to predict their effectiveness when donors need those medication in the future. We also examined the effects of several mutations in two different genes (Filamin-C and Presenilin-2) that can induce arrhythmia and sudden cardiac death. By in-depth molecular target identification, gene- or mutation- specific therapy may be developed.
Speaker’s Bio: Dr. Lam is an assistant professor in the Department of Biological Sciences at the University of Delaware. He earned his PhD degree at the University of Cincinnati, and subsequently complete his post-doctoral training at Stanford University. His research program aims to advance our understanding on cardiac biology and establish drug testing platforms for translational impact. Particularly, his research lab is interested at understanding how calcium regulation and stress response pathways contribute to the pathogenesis of various cardiac diseases. Moreover, his lab is interested at examining the cardiotoxicities of various cancer agents, in order to develop strategy to limit their cardiovascular side effects. Ultimately, Dr. Lam is interested at identifying strategies to simultaneously target multiple disease mechanisms to treat both genetic and acquired forms of cardiac diseases.


November 2
6:00 pm - 7:00 pm


Department of Biology