Biology Colloquium | Jie Yan
April 14 @ 1:30 pm - 2:30 pm
Title: The mechanical responses of tension-transmission supramolecular linkages
Abstract: The task of mechanosensing of cells involves dynamic assembly of various tension-transmission supramolecular linkages, which enable the cells to properly sense and respond to the level of tension in the linkages. A tension transmission linkage typically consists of a few non-covalently linked proteins, in which the domains and protein-protein interfaces are subject to dynamic fluctuation of intracellular tensions. This leads to highly complex tension dependent connectivity of the supramolecular linkages, conformational changes of the domains and the resulting tension-dependent interactions of binding sites in the linkage with signalling proteins.
Increasing evidence has suggested that protein-protein interfaces and protein domains in various mechanosensing tension-transmission supramolecular linkages have been evolved with special structural and topological features that impart them with special mechanical properties. In this talk, I will introduce our recent single-molecule and theoretical investigations of the effects of the structural-topological features shared by many tension bearing protein-protein interfaces and protein domains on the mechanical stability and mechanosensing function of tension-transmission supramolecular linkages.