Biology Colloquium | Lalit Beura
October 12 @ 6:00 pm - 7:00 pm
- This event has passed.
The Department of Biology invites you to a Colloquium on October 12, 2021 (Tuesday)
Speaker: Lalit Beura
Assistant Professor, Brown University
Title: Resident memory CD8 T cells: Not just frontline soldiers
Time: 06:00 PM – 07:00 PM
Meeting ID: 948 9608 8942
Abstract: Memory CD8 T cells are critical to our defense against intracellular pathogens and tumors. While they were initially thought to constantly migrate between barrier organs, blood and lymphoid tissues to survey the body for evidence of infection, recent studies have shown that a significant fraction of memory CD8 T cells remain permanently positioned in frontline barrier tissues. These so-called “resident memory T cells (TRM)” eliminate pathogens through a variety of mechanisms and their presence is often associated with a rapid halt in the progression of disease. I will describe our current understanding of the TRM- mediated anti-pathogenic defense system and provide evidence of TRM’s new role in systemic immunosurveillance. I will also provide a brief summary of our work with “dirty mice ” model that is aimed to recapitulate traits of the adult human immune system unlike the currently used laboratory mice.
Speaker’s Bio: Lalit Beura is an Assistant Professor in the Department of Molecular Microbiology and Immunology, Brown University. His research focuses on mucosal T lymphocyte biology. He received his Ph.D. in Molecular Virology from the University of Nebraska working on PRRSV host-pathogen interaction under Fernando Osorio. Lalit was a post-doctoral associate at the University of Minnesota with David Masopust, where he worked on antiviral resident memory T cell function. He joined the Brown faculty in late 2019. He is a 2021 Searle Scholar.