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Dilip Kumar

Assistant Professor, Trivedi School of BioSciences, Ashoka University

Ph. D. (Biotechnology)

Dilip Kumar is a trained structural biologist. He uses X-ray crystallography and cryogenic electron microscopy to visualize the native structure of macromolecular complexes and viral assemblies. Dr. Kumar completed his M.Sc. in Biomedical Sciences at Ambedkar Center for Biomedical Research, Delhi University. 

He was in CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, for his doctoral research. There he worked on nucleic acid modulating enzymes from mycobacteria and determined the first full-length structure of mycobacterial nanoRNase. Later, Dr. Kumar joined the Prasad Lab at Baylor College of Medicine, Houston, USA, for his postdoctoral research. His research at Baylor focused on the structural and functional aspects of replication and transcription machinery of rotaviruses, a major gastroenteric pathogen, and successfully determined the first full-length cryo-EM structure of rotavirus capping machinery.

Dr. Kumar’s lab at Ashoka University focuses on pathogenic viruses’ replication and transcription processes and the therapeutic potential of neutralizing monoclonal antibodies against viral infections. He is also keen on devising novel antiviral strategies against emerging viruses.

  1. Dilip Kumar, Xinzhe Yu, Sue E. Crawford, Rodolfo Moreno, Joanita Jakana, Banumathi Sankaran, Ramakrishnan Anish, Soni Kaundal, Liya Hu, Mary K Estes, Zhao Wang, B. V. Venkataram Prasad. 2.7 Å Cryo-EM structure of rotavirus core protein VP3, a unique capping machine with a helicase activity. Science Advances,  15 Apr 2020: Vol. 6, no. 16, eaay6410.
  2. Mitra S, Kumar D, Hu L, Sankaran B, Moosa MM, Rice AP, Ferreon JC, Ferreon ACM, Prasad BVV. Influenza A virus protein NS1 exhibits strain-independent conformational plasticity. J Virol. 2019 Aug 2. 917-919. Doi: 10.1128/JVI.00917-19.
  3. Srivastav R, Kumar D, Grover A, Singh A, Manjasetty B, Sharma R, Taneja B. Unique subunit packing in mycobacterial nanoRNase leads to alternate substrate recognitions in DHH phosphodiesterases. Nucleic Acids Res. 2014 Jul; 42(12):7894-910.

Dilip Kumar, Xinzhe Yu, Sue Crawford, Liya Hu, Mary K Estes, Zhao Wang, BVV Prasad. Cryo-EM structure of rotavirus VP3 reveals novel insights into its role in RNA capping and endogenous transcription. Springer Nature Book Chapter (Applications of Microscopy in Materials and Life Sciences, 211-220).

  1. Saleh Wakil Memorial prize for oral presentation at BMB/PHARM/CPSB research conference.
  2. OPCW (Organization for Prohibition of Chemical Weapons) International travel grant for International school of crystallography 45th course: Present and future Methods in Biomolecular Crystallography, Erice, Italy. 
  3. Americal Society for Virology (ASV) travel grant for Oral presentation at ASV2019, University of Minnesota, USA.
  4. NIH travel award for Shotgun talk at 13th International dsRNA virus symposium, Houffalize, Belgium.
  5. Department of Science and Technology (DST, Govt. of India) travel award to perform X-ray Diffraction at XRD-1 beam line, Elettra synchrotron, Trieste, Italy.

BIO-4234-1 (Cells and molecules of life)

BIO-3006/ BIO-6006-1 (Understanding Structure and Function)

BIO-3005/ BIO-6009/ CS-2455-1 (Biostatistics and Bioinformatics)

BIO-4206/ BIO-6206-1 (Genomics & next-generation sequencing)

Study at Ashoka

Study at Ashoka