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Sourav Chatterjee

Assistant Professor of Chemistry, Ashoka University

Ph.D. CSIR-Indian Institute of Chemical Biology, Kolkata, India

Sourav obtained his doctoral degree in 2017 from CSIR-Indian Institute of Chemical Biology in Kolkata, India. During his doctoral tenure, he worked on developing phosphoric acid-based chiral organocatalysts, where his work centered on elucidating novel reaction methodologies to induce point chirality and axial chirality in molecular systems anchored in indole and pyrrole frameworks.

After his Ph.D., Sourav had opportunities to pursue postdoctoral research experience at (1) Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India, (2) The Scripps Research Institute, Florida, USA and (3) University of Minnesota, Minneapolis, USA. These postdoctoral trainings propelled his expertise in bridging the realms of chemistry and biology, with a specific focus on elucidating disease-associated biological conundrums through advanced chemical approaches. His research endeavors encompassed the development of synthetic and natural product-based semisynthetic small molecule modulators aimed at regulating intricate protein post-translational modifications, specifically protein methylation, acylation, glycosylation, and protein hydroxylation.

Sourav’s current research interests lie in both chemistry and chemical biology/medicinal chemistry. His lab’s primary focus in chemistry would be to develop new reaction methodologies, designing optically pure catalysts and ligands, and use of sustainable enzymes to investigate stereoselective reaction outcomes. At the interface of chemistry and biology, his research interest will focus on crafting chemical biology tools through the scalpel of small molecule modulators that can regulate the activity and function of epigenetic enzymes relating to chromatin modifications.

  • Electrostatically regulated active site assembly governs reactivity in non-heme iron halogenases. Elizabeth R. Smithwick, Hunter R. Wilson, Sourav Chatterjee, Yu Pu, Joseph J. Dalluge, Anoop Rama Damodaran, and Ambika Bhagi-Damodaran. BioRxiv, May 2023. doi: https://doi.org/10.1101/2023.05.25.542349.
  • A newly synthesized 3-indolyl furanoid inhibits matrix metalloproteinase-9 activity and prevents nonsteroidal anti-inflammatory drugs-induced gastric ulceration. Deep S. Rudra#, Sourav Chatterjee#, Uttam Pal#, Madhumita Mandal, Susri Ray Chaudhuri, Mrinmay Bhunia, Nakul C. Maiti, Shila E. Besra, Parasuraman Jaisankar, and Snehasikta Swarnakar. Med. Chem. 2023. https://doi.org/10.1021/acs.jmedchem.3c00511 # Equal contribution.
  • Catecholase catalyzed synthesis of wedelolactone, a natural coumestan and its analogs. Anushree Achari#, Sourav Chatterjee#, Sudip Dey, S.; Tapas K. Kundu, and Parasuraman Jaisankar. Org. Biomol. Chem. 2023, 21, 89-92. # Equal contribution.
  • Role of secondary coordination sphere residues in halogenation catalysis of non-heme iron enzymes. Hunter R. Wilson, Sourav Chatterjee, Elizabeth Smithwick, Joseph Dalluge, and Ambika Bhagi-Damodaran. ACS Catal. 2022, 12, 10913–10924.
  • Butyrylation meets adipogenesis – probed by p300 catalyzed acylation specific small molecule inhibitor: Implication in anti-obesity therapy. Aditya Bhattacharya, Sourav Chatterjee, Utsa Bhaduri, Akash Kumar Singh, Madavan Vasudevan, Koneni V. Sashidhara, Rajdeep Guha, Aamir Nazir, Srikanta Kumar Rath, Nagashayana Natesh, and Tapas K. Kundu. J. Med. Chem. 2022, 65, 18, 12273–12291.
  • Bis-indole/carbazole based C5-Curcuminoid fluorescent probe with large Stokes shift for selective detection of biothiol and application to live cell imaging. Pinaki Bhattacharjee, Sourav Chatterjee, Anushree Achari, Abhijit Saha, Debkumar Nandi, Chiranjit Acharya, Kasturi Chatterjee, Surajit Ghosh, Snehasikta Swarnakar, Parasuraman Jaisankar. Analyst, 2020, 145, 1184-1189.
  • Silencing glycosaminoglycan functions in mouse embryonic stem cells with small molecule antagonists. Sourav Chatterjee, Tesia N. Stephenson, Austen L. Michalak, Kamil Godula, and Mia L. Huang. Methods in Enzymology, 2019, 626, 249-270.
  • Establishment of atropisomerism in 3-indolyl furanoids: A synthetic, experimental and theoretical perspective. Sourav Chatterjee, Pinaki Bhattacharjee, Glenn L. Butterfoss, Anushree Achari, and Parasuraman Jaisankar. RSC Advances 2019, 9, 22384-22388.
  • Fiaud’s acid: A Brønsted acid catalyst for enantioselective Friedel-Crafts alkylation of indoles with 2-alkene-1,4-diones. Sourav Chatterjee, Lukas Hintermann, Madhumita Mandal, Sreya Gupta, Anushree Achari, and Parasuraman Jaisankar. Org. Lett. 2017, 19, 13, 3426-3429 (highlighted in Synfacts).
  • Racemization barriers of atropisomeric 3,3′-bipyrroles: An experimental study with theoretical verification. Sourav Chatterjee, Glenn L. Butterfoss, Madhumita Mandal, Richard Bonneau, Bishwajit Paul, Sreya Gupta, and Parasuraman Jaisankar. RSC Advances 2016, 6, 71245-71249.
  • Synthesis of bis-pyrrolizidine-fused dispiro-oxindole analogues of curcumin via one-pot azomethine ylide cycloaddition: Experimental and computational approach toward regio- and diastereoselection. Yogesh P. Bharitkar, Mohua Das, Neha Kumari, M. Padma Kumari, Abhijit Hazra, Sagar S. Bhayye, Ramalingam Natarajan, Siddharth Shah, Sourav Chatterjee, and Nirup B. Mondal. Org. Lett. 2015, 17, 18, 4440-4443.
  • Indium trichloride catalyzed sp3 C–H bond functionalization of 2-alkyl azaarenes under microwave irradiation. Sourav Chatterjee, Pinaki Bhattacharjee, Jagadeesh Temburu, Debkumar Nandi, and Parasuraman Jaisankar. Tet. Lett. 2014, 55, 6680–6683.
  • Woollins Reagent: A chemoselective reducing agent for 1,4-enediones and 1,4-ynediones to saturated 1,4-diones. Madhumita Mandal, Sourav Chatterjee, and Parasuraman Jaisankar. Synlett 2012, 23, 2615-2618.
  • Methods, compositions, and reagents for preparing compounds. Ambika Bhagi-Damodaran, and Sourav Chatterjee. US Patent, 2023 (Application Number 17/976,580).
  • Small molecule tethers for selective targeting of metalloenzymes. Ambika Bhagi-Damodaran, Leonardo Rander Asse Jr., and Sourav Chatterjee. US Provisional Patent 2022 (Application Number 63235610).
  • Small molecule modulator targeting a rare histone modification, regulating adipogenesis and pharmaceutical formulation thereof. Tapas K Kundu, Aditya Bhattacharya, Sourav Chatterjee. Indian Provisional Patent 2021 (Application Number 050515).
  • 3-Indolyl furanoids as inhibitors of matrix metalloprotease-9 for prevention of gastric ulcer and other inflammatory diseases. Parasuraman Jaisankar, Snehasikta Swarnakar, Sourav Chatterjee, Sugreev Verma, Madhumita Mandal, Susri Ray Chaudhuri. US Patent 2018 (Application Number 15897688).
Study at Ashoka

Study at Ashoka