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Other links:

Simantini Ghosh

Assistant Professor of Psychology, Ashoka University

Ph.D. University of Rochester School of Medicine and Dentistry

Simantini (Simi) Ghosh conducts research on traumatic stress.

Her research focuses on gender-based violence, systemic discrimination, and their impact on survivors, specifically examining psychological dysfunction in the context of cumulative trauma rather than acute exposure to a single traumatic event. She is also interested in exploring patterns of familial violence and its intergenerational consequences. The overarching aim of this research is to move beyond traditional clinical constructs of PTSD, reframing trauma as a psychosocial issue and investigating its impact on survivors even when diagnostic criteria are not met. The research methodology encompasses qualitative, quantitative, and mixed-methods designs. These efforts are increasingly diversifying to incorporate experimental psychological approaches.

A second, neuroscience-based strand of research in her lab investigates the molecular neurobiology of traumatic stress in rodents, with a primary focus on neuroimmunology. This work employs various rodent behavioral paradigms related to stress, including learned helplessness and other behavioral assays. Analytical techniques include molecular biology, biochemistry, immunohistochemistry, microscopy-based approaches, and cell culture methods.

Her background has evolved from neuroscience to psychology. She studied neurodegeneration and neuroinflammation , traumatic brain injury and chronic and acute traumatic stress in the past. She earned a PhD in Neurobiology and Anatomy at the University of Rochester School of Medicine and Dentistry, NY  and pursued her postdoctoral fellowship in Neurology at the Washington University School of Medicine in Saint Louis, MO prior to joining Ashoka. She enjoys teaching courses that straddle both neuroscience and psychology, as well as research methods courses.

Outside work she enjoys reading poetry and nonfiction, listening to classic rock, jazz and blues.

ORCID

Research Gate profile 

Academia profile  

LinkedIn Profile 

Published articles

  • Ghosh, S*., Mohammed, Z., & Singh, I. (2021). Bruton’s tyrosine kinase drives neuroinflammation and anxiogenic behavior in mouse models of stress. Journal of neuroinflammation18(1), 1-26.  https://doi.org/10.1186/s12974-021-02322-9
  • Ghosh S (2020) Decoding Gendered Online Trolling in India in Mirchandani (Ed.), Tackling Insurgent Ideologies in a Pandemic World 59-64 (ORF and Global Policy Journal, 2020) (https://www.orfonline.org/research/tackling-insurgent-ideologies-in-a-pandemic-world/)
  • Rivera-Escalera, F., Matousek, S. B., Ghosh, S., Olschowka, J. A., & O’Banion, M. K. (2014). Interleukin-1u03b2 mediated amyloid plaque clearance is independent of CCR2 signaling in the APP/PS1 mouse model of Alzheimer’s disease. Neurobiology of Disease, 69, 124-133. https://doi.org/10.1016/j.nbd.2014.05.018
  • Ghosh, S., Wu, M. D., Shaftel, S. S., Kyrkanides, S., Laferla, F. M., Olschowka, J. A., & O’banion, M. K. (2013). Sustained interleukin-1  overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer’s mouse model. Journal of Neuroscience, 33, 5053-5064. https://doi.prg/10.1523/jneurosci.4361-12.2013
  • Matousek, S. B., Ghosh, S., Shaftel, S. S., Kyrkanides, S., Olschowka, J. A., & O’Banion, M. K. (2011). Chronic IL-1u03b2-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer’s disease without inducing overt neurodegeneration. Journal of Neuroimmune Pharmacology, 7, 156-164. https://doi.org/10.1007/s11481-011-9331-2

 

Preprints (Currently in review) 

  • Tiwari S, Mohammad Z, Atta SR, Kaushik S, Tiwari A, Chopra A, Singh I, Ghosh S*. BTK-NLRP3-Caspase1 and Gasdermin D-Caspase 11 pathways jointly drive neuroinflammation and functional impairments in a rat model of psychosocial stress (2025)  
    ( Journal of Neuroinflammation
  • Purohit, A., & Ghosh, S*. (2024). Coping Strategies as Mediators in Promoting Posttraumatic Growth in Indian Young Adults’ Experiences of Sexual Harassment. https://doi.org/10.31234/osf.io/8j5tz
  • Jindal, S., Budhraja, M., & Ghosh, S*. (2024). Help-Seeking Behavior for Mental Health Concerns among Indian young adults. https://doi.org/10.31234/osf.io/gavuw
  • Mete, A., & Ghosh, S*. (2022). Understanding Pathways of Intergenerational Transmission of Familial Violence in India through Complex Trauma Theory. https://doi.org/10.31234/osf.io/drjg8
  • Ghosh, S.*, & Vohra, N. (2021). Procrastination and Anxiety among Indian college students: The role of perceived parenting styles, locus of control and self efficacy. https://doi.org/10.31234/osf.io/wbf5v

Manuscripts in preparation:

  • Tiwari S, Kaushik S, Mohammad Z, Atta SR, Chopra A, Singh I, Ghosh S*. TRIM21 induces  NLRP3 inflammasome activation through the non canonical pathway.  (preparing for submission in Brain, Behaviour and Immunity)
  • Roy M, and Ghosh S*. Theoretically deconstructing rape using a social-cognitive lens (preparing for submission in Sex Roles) 
  • Sen M, Khandelwal S, Rajvanshi S and Ghosh S*. Remapping domestic violence in India using complex trauma- a theoretical bridge (Preparing for submission in Journal of Traumatic Stress) 

Current Research Interests:
My broad research interest lies in understanding how chronic, unpredictable traumatic stress affects the mind and the psychological, sociocultural, neurobiological and neuroinflammatory components that underlie stress responses. Research and approaches span disciplines and techniques, but the central theme is focused on understanding the sequelae of chronic stress and by extension, developing interventions and targets for stress related disorders.
Current Projects:

  1. Studying domestic violence using  complex trauma theory
  2. Studying psychological variables that might moderate or mediate how emotional trauma affects mental health
  3. Studying generational trauma
  4. Studying neuroimmune responses underlying traumatic stress, using rat models of stress, behavioral and molecular readouts. For now, focusing on the NLRP3 inflammasome pathway.

Prior Areas of Training: 
Neuroinflammation in the context of neurodegenerative and neurocognitive disorders, particularly Alzheimer’s disease, tauopathies and traumatic brain injury.  Prior projects include

  • Consequences of sustained overexpression of Interleukin-1 Beta, a master regulator of the brain’s Immune response in murine models of Alzheimer’s disease and tauopathy.
  • Repetitive Concussive traumatic Brain Injury rodent models as developed in the Laboratory of Dr. David Brody at Washington University (Currently at NINDS) and the effects of such injuries in the dendritic spine compartments of cortical neurons.
  • Testing the toxicity of human Alzheimer’s brain derived high molecular weight oligomeric fractions in rodents by performing stereotaxic delivery into the mouse hippocampus, followed by immunohistochemical and behavioral characterization.

Articles in the Indian Express

Indian Express Columnist Profile

Unedited versions of the articles can be accessed through the links below

  • Ghosh S (2024) Kolkata doctor’s death reminds us, the personal is still political. The Indian Express, August 19(Opinion)
  • Ghosh S (2024) Elon Musk’s Neuralink is a minefield of scientific and ethical concerns. The Indian Express, February 9 (Opinion)
  • Ghosh S (2023) Why approval for Elon Musk’s Neuralink for humans is a bad idea. The Indian Express, June 12 (Opinion)
  • Ghosh S (2022) Not Hindu-Muslim, not married-unmarried — domestic violence in India is more universal. The Indian Express, December 22 (Opinion)
  • Ghosh S (2020) Open Letter to Fellow parents and teachers: We need ensure our children receive gender education from early on, The Indian Express, May13 (Opinion)
  • Ghosh S (2019) Naive like a puppy, The Indian Express, July 27 (Opinion)
  • Ghosh S (2018) In Good Faith: the tyranny of positive thinking , The Indian Express. June 9 (Opinion)

Articles in the Outlook magazine :

Other articles in the media: 

Articles where I have been interviewed :

Growing gender gap in STEM jobs in India

https://researchmatters.in/news/partner-or-perpetrator-understanding-causes-and-consequences-intimate-partner-violence

https://www.outlookindia.com/newsscroll/domestic-inequality-in-sharp-focus-with-lockdown/1828840

https://asia.nikkei.com/Life-Arts/Life/Has-India-s-most-influential-guru-finally-gone-too-far

Students requesting letters of recommendation, should note the following:

  • I feel uncomfortable writing letters for students who have not worked with me on a research problem/project either as a thesis or an ISM student. This is simply because it is not always possible to gauge anyone’s ability from a class, unless it is a class of ten or twelve. Even if I do write a letter in that capacity, I will only be able to comment on your potential as I have seen in the course(s) that you have taken with me. Decide how much advantage that will give you before you ask.
  • I request that you do not ask me to write more than 6 letters. With multiple students each applying to many places, it becomes overwhelming very quickly
  • I ask the following documents at least 3-4 weeks in advance
    • A current, up to date CV
    • Statement of purpose you are going to use for your application
    • Your Ashoka transcript (screenshots work too, just an assessment of your grades from years 1-4)
    • A spreadsheet with the following details for each school that you apply for
      • Name of the program, department and University
      • Link to the program page
      • Deadline for submission of LOR
      • If there is a specified link for LOR submission, provide that, or any prescribed format, or specific instructions for submission, put it there.
  • Assemble all the documents within a shared Google Drive folder with your name on it, and share it with me with edit access.
  • If you have worked within an ISM with a project coordinator, keep them looped in the emails and drafts you may provide.

 

Dear Students,

In your 4th (ASP) year, there are both thesis and non-thesis tracks, both of which will enable you to get research experience.

The thesis track:

A thesis track (12 credits) will be divided into thesis proposal (4 credits) and thesis (8 credits) over the monsoon and the spring semester of your ASP year. There is a tight timeline with respect to several stages of the process, and submission of several drafts of the proposal and the final thesis will be required on specific dates.

For a sample timeline, please use the 2024 timeline. Course manuals for PSY4998 (Thesis Proposal) and PSY4999 (Thesis) can be found here : ASP Syllabus 2024-25  https://docs.google.com/document/d/1MUJ7xZumyRNqMblvvbQBKXv-1CwnisDvNjX00JsUoKI/edit?usp=sharing

An honors thesis is a capstone course where students will complete a piece of original scholarly work that contributes substantially to the knowledge and/or application of the discipline. Doing a thesis requires a substantial amount of research skills, commitment, and time management skills.

Please do not enter the thesis track lightly. A thesis is a student’s independent idea and the formulation of the research questions, methodological decisions and analysis is mostly dependent on the student, with a general oversight by the advisor. While accepting thesis students, I try to assess whether the project conceptualization is strong enough to make an independent publication in a peer reviewed journal.

Thesis application form: https://forms.gle/rFsBfQxhBVouH2ocA

For the foreseeable future I will only be accepting thesis students whose research interests are allied with gender based violence and mental health.

The Independent Study Module (ISM) /Advanced ISM track:

An ISM/ advanced ISM is an avenue to gain hands on research experience with me on my research projects. The theoretical conceptualization and research question formulation is directly under my supervision, and students help collect data, and analyze them. When we publish, you get co-authorship/ acknowledgement depending on your involvement, diligence and the quality of work you produce.
A list of my currently running projects, names of the coordinators for each project can be found here: https://docs.google.com/spreadsheets/d/1xwoMZF6au2PEfnYGduRkIXCn_Wfu7MCw1gK4g5BcFhU/edit#gid=0
The same sheet has also been circulated with the psychology representatives.

If you are interested to join any of my projects, please contact the coordinators mentioned in the sheet, read the documentation on the project, understand where the work is, and fill out the form for application by May 15 ( summer research) or July 30(For Monsoon 22). Then send me an email.  Most of my projects can span over multiple semesters, so ISM students can expect to be a part of a specific phase of a larger, ongoing project. PLEASE DO NOT RAISE ISM REQUESTS ON AMS WITHOUT TALKING TO ME FIRST. This is a form I ask to fill before I accept an ISM student: https://forms.gle/25ATaSTCdutg8Ke1A

We are always looking for bright and motivated students to join our research initiatives. Passionate and curious about research? I usually look at three things while evaluating one’s application, other than consistency in your academic achievements.

  • Research aptitude – Research has to be a passion. Additionally, you do need to have idea about basic statistical concepts, null hypothesis significance testing and research methods. For psychology majors I ask for SRMII as a prerequisite. Students from other programs can show me other coursework that they have taken at Ashoka or elsewhere . Most of my projects will need students to come with a working knowledge of  point estimates, power calculations and effect sizes, regression, ANOVAs and familiarity with NHSTs in general. You have to show me proof of coursework in these areas, just claiming familiarity will not be enough. From time to time we may need people trained in certain kinds of qualitative methodologies but those internship opportunities are advertised separately.
  • Ethics and integrity– Research ethics and integrity are very important for me and everyone i my group. If you come to my research group, please know that I have a zero tolerance policy towards plagiarism and any tampering with raw data. This lies at the core of research. Good data is not necessarily sensational data. There will never be any compromise with methodological rigor.
  • Interpersonal skills– Community engagement and knowledge of Hindi are essential if you’re interested in the psychology based projects. We can teach you good interviewing skills, but if you have a flair for talking to people from all socioeconomic and political backgrounds, it will help you manifold. Also, the environment in our group is very collegial, people collaborate rather than competing within the group. These qualities are very important for me to consider too.

So if our any aspect of our research excites you, and you would be interested to work with us, please write to me with a CV, a transcript that shows all coursework you have taken in psychology and a one page statement of interest. (what project(s) already described or what new project that aligns with the broader interest of my group would you liked to be involved in and why? What kind of methodological/statistical training do you have? )

We look forward to reading your applications!

Study at Ashoka

Study at Ashoka

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