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Sandeep Ameta

Assistant Professor of Biology, Ashoka University

Ph.D. Heidelberg University

Sandeep is an experimentalist interested in building evolvable synthetic systems using interdisciplinary approaches. Despite immense efforts, how to build a synthetic chemical system that can evolve and what constitutes it remains an open question. Similarly, the series of steps that led to the emergence of self-sustaining living systems on the early Earth is still elusive. To address some of these questions, he is developing synthetic chemical systems capable of undergoing evolution and demonstrating ‘life-like’ features. In addition, he is also interested in deciphering the dynamics of functional RNAs and evolving them in complex environments. His work revolves around self-replicating chemical systems, aptamers, ribozymes, liquid-liquid phase-separated droplets, droplet-based microfluidics, and other single-molecule biophysical methods.

Before joining Ashoka, Sandeep was an independent Campus fellow at the Simons Centre for the Study of Living Machines at the National Centre for Biological Sciences (NCBS), Bangalore. Prior to that, he was a postdoctoral fellow at ESPCI Paris (École supérieure de physique et de chimie industrielles de la Ville de Paris), France and PhD student at Heidelberg University, Germany. He did his Master’s in Biotechnology from the Indian Institute of Technology Bombay (IIT Bombay) and his Bachelor’s in Biotechnology from the University of Rajasthan.

 

  • Singh A., Thutupalli S. Kumar M.*, Ameta S.* (2024) Constrained dynamics of oligonucleotides in phase-separated droplets. J., 123, 1-9.
  • Ameta S.*, Kumar M., Chakraborty N., Matsubara Y., Gandavadi D., Prashanth S., Thutupalli S.* (2023) Multispecies autocatalytic RNA reaction networks in coacervates. Chem. (Nature), 6, 91.
  • Ameta S., Blokhuis A., Jeancolas C., Nghe P. (2022) Toward evolution in chemical reaction networks. Page no: 379-423, Book: Prebiotic Chemistry and Life’s Origin, Royal Society of Chemistry (ISBN 978-1-78801-749-7).
  • Ameta S.*, Mastubara Y., Chakraborty N., Krishna S., Thutupalli S (2021) Self-Reproduction and Darwinian Evolution in Autocatalytic Chemical Reaction Systems. Life (Basel), 11, 308.
  • Jeancolas C., Matsubara Y.J., Vybornyi M., Lambert C.N., Blokhuis A., Alline T., Griffiths A.D., Ameta S., Sandeep Krishna, Philippe Nghe. (2021) RNA diversification by a self-reproducing ribozyme revealed by deep sequencing and kinetic modelling. Commun., 57, 7517-7520.
  • Ameta S.ǂ, Arsène S.ǂ, Foulon S., Saudemont B., Clifton B.E., Griffiths A.D., Nghe P. (2021) Darwinian properties and their trade-offs in autocatalytic RNA networks. Commun., 12, 1-11.
  • Deyell M., Ameta S., Nghe P. (2019) Large scale control and programming of gene expression CRISPR. Cell Dev. Biol., 96, 124-132.
  • Ameta S.* and Menafra R. (2019). RNA Sequencing Technology for Biomedical Sciences” Book: Cutting Edge Techniques in Biophysics, Biochemistry and Cell Biology: From Principle to Applications. Bentham Science Publisher, ISBN: 978-981-14-2285-0.
  • Arsène S.ǂ, Ameta S.ǂ, Lehman N., Griffiths A.D., Nghe, P. (2018) Coupled catabolism and anabolism in autocatalytic RNA sets. Nucleic Acid Res., 46, 9660–9666.
  • Ameta S.ǂ, Becker J.ǂ and Jäschke A. (2014) RNA–peptide conjugate synthesis by inverse-electron demand Diels–Alder reaction, Biomol. Chem., 12, 4701–4707.
  • Ameta S.ǂ, Winz M.-L.ǂ, Previti C. and Jäschke A. (2014) Next-generation sequencing reveals how RNA catalysts evolve from random space. Nucleic Acid Res., 42, 1303-1310.
  • Ameta S. and Jäschke A. (2013) An RNA catalyst that reacts with a mechanistic inhibitor of serine proteases. Sci., 4, 957-964.
  • Schoch J.ǂ, Ameta S.ǂ and Jäschke A. (2011) Inverse electron-demand Diels-Alder reactions for the selective and efficient labelling of RNA. Comm., 47, 12536-12537.

Monsoon Semester:

  • Chemical Basis of Life (Core Course, BIO-2300/ BIO-6300-1)
  • Synthetic Biology (Elective, BIO-3455-1)

Spring Semester:

  • Research Methodology and Ethics (Core Course, BIO-6603/ BIO-4209/ CHM-6606-1)
  • Molecular evolution (Elective, BIO-3102/ BIO-6102-1)
  • Synthetic Biology (Elective, BIO-3455/ BIO-6455-1)
Study at Ashoka

Study at Ashoka

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